San Francisco 49ers vs St Louis Rams NFL Picks Week 17

San Francisco 49ers vs St Louis Rams NFL Picks Week 17: With a franchise-worst record six straight losing season, the (7-8) San Francisco 49ers [-8] will look to snap that streak in the season finale versus the sports betting odds underdog (1-14) St Louis Rams [+8] today. This NFC West divisional matchup kicks off at 1:05 PM ET live from Edward Jones Dome on FOX.

San Francisco 49ers vs St Louis Rams NFL Picks Week 17After a 3-1 start, the Niners seemed poised for a postseason berth this season. But after that hot start, San Francisco stumbled a bit, losing four straight games and taking itself out of playoff contention in the National Football Conference. The Niners were mathematically eliminated with a 27-13 loss to Philly in NFL Picks Week fifteen. The OVER/UNDER for this San Francisco 49ers vs St Louis Rams NFL Picks Week 17 game is set at a combined total of 45 points scored.

Nevertheless, something positive can come out of Frisco’s playoff-less season. In his first full season at the helm, coach Mike Singletary now has the chance of snapping an atrocious streak of six consecutive losing seasons. A win today would give Frisco 8 wins on the season, the most since 2002, when the team captured an NFC West title with a 10-6 mark.

"The biggest thing is winning, however we've got to do it," said Pro Bowl bound linebacker Patrick Willis. "We've got to get it done. We want to finish 8-8, which would be .500. That would be the first time our team has done that in a while, so that would be big. Also, too, just going into the offseason with a win always helps."

For the Rams, losing one more game would bring joy to its fans, if that makes any sense. Going into the season finale, St Louis is just one loss away from securing the first overall pick in the upcoming 2010 NFL Draft. However, don’t tell that to head coach Steve Spagnuolo, who’s still focused on the task in front of him.

"I'll worry about that in a couple of weeks," Spagnuolo said. "We're neck and neck in trying to win a game. It's the last one and we're going to play it to win it."

Cash in with sign-up bonuses, weekly reload bonuses and free payouts at, where betting is safe, secure and easy. I like Frisco [-8] to finish strong!