San Francisco 49ers vs Indianapolis Colts Odds 2010 NFL Preseason Week 1: After suffering a devastating defeat last February in Miami, Florida, the Indianapolis Colts [+3] are ready to jump on the horse once again, as they open their 2010 NFL Preseason by hosting the sports betting odds favorite San Francisco 49ers [-3] today. This 2010 NFL Preseason matchup is scheduled to kick off this afternoon at 1:05 PM ET (12:05 PM CT) live from Lucas Oil Stadium.
In case you are wondering why in the world are the Niners favorites on the road in this one, all you have to do is 
take a look at the Indy’s depth chart for this one. According to 2010 NFL Preseason Week 1 specialists at SBGGLOBAL.com, the OVER/UNDER between the San Francisco 49ers and Indianapolis Colts has been set at a combined total of 33½ points scored.
The biggest concern for Jim Caldwell this week was the injury to his Pro Bowl tight end Dallas Clark, who couldn’t finish practice after hurting his left leg. Clark was in the middle of running a route when the injury occurred and thus, Caldwell declared him out for today’s opener.
Last season, Clark tied Reggie Wayne for the team lead in: receptions with 100 and touchdown grabs with 10. "Just got a bit of a little tweak," Caldwell said. "He won't play in the game obviously, but he'll be back soon."
Other Colts missing in action for today’s game against Frisco include: Dwight Freeney, Anthony Gonzalez, Keyunta Dawson, Pierre Garcon, Clint Session, Ramon Humber, Charlie Johnson, Jeff Saturday and Jacques McClendon.
Bet on San Francisco 49ers vs Indianapolis Colts Odds 2010 NFL Preseason Week 1 at internet sportsbook SBG Global and receive up to 295% in Cash Bonuses and start winning today!
