NFL Predictions Arizona Cardinals vs. San Francisco 49ers: For a third consecutive season, the Arizona Cardinals and the San Francisco 49ers kickoff the NFL season-opener against one another. Also, for a second year in a row, the Cardinals begin their season on the road and at Candlestick Park in Frisco. Arizona will start their NFL season on the road for the 19th time in the last 21 years.

At LooseLines.com the Arizona Cardinals are -2½ betting odds favorites against the San Francisco 49ers (+2½) . This NFC West divisional showdown has a scheduled kickoff start of 4 PM ET (1 PM PT).

For Arizona, this will be the only NFC West opponent that they’ll face until week 9 of the NFL regular season, when they travel to St. Louis to take on the Rams.

The Cardinals will kickoff their home opener next week when they return to the Valley to host the new-look Miami Dolphins. This afternoon, Miami opens their season at home against Brett Favre and the New York Jets.

On Saturday of last week, Cards head coach, Ken Whisenhunt officially announced that veteran QB Kurt WarnerMatt Leinart for the starting position. The OVER/UNDER in this NFC West in this NFL Predictions: Arizona Cardinals (-135) vs. San Francisco 49ers (+115) has been set at a total of 42 points . had beaten

For the 37-year-old Warner, he has been around long enough to understand the nature of this business: “It’s probably rare to see it play out this way than the other… you also realize in this business, you want to win now and who’s going to give us that best chance to win now.”

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