San Francisco 49ers at Arizona Cardinals NFL Week 1 Picks

San Francisco 49ers at Arizona Cardinals NFL Week 1 Picks: The 49erss head to Arizona to take on the Cardinals under rookie head football coach Mike Singletary to kick off the 2009 NFL Regular season Sunday at 4:15 PM EST on FOX. The NFL Week 1 Picks experts at online sportsbook have the Arizona Cardinals -6.5 point favorites at home against the San Francisco 49ers.

San Francisco 49ers at Arizona Cardinals NFL Week 1 PredictionsThe Cardinals have won six of the past eight meetings, but the 49ers still own a 19-16 overall edge in the series.  The next chapter in the Larry Fitzgerald saga is coming off perhaps the greatest postseason by a wide receiver in NFL history. He had 30 catches for 546 yards and seven touchdowns in four playoff games, and even caught a TD in the Pro Bowl. Is it possible for him to maintain that production throughout a full season? He begins that quest Sunday. The NFL Week 1 Picks experts at have the 49ers vs Cardinals Total set at 46 points

Niners QB Shaun Hill's adjustment to being a full-time starter: For the first time in his seven-year career, Hill enters the season as a starter. If he wants to hold onto that job, he needs to produce. His first chance to do so comes against the Cardinals in Week 1.  San Francisco WR Isaac Bruce ranks second in career receiving yards (14,934) all-time. 49ers TE Vernon Davis has caught a touchdown in three straight games against the Cardinals and Cardinals QB Kurt Warner has won nine of his 10 career starts against the Niners.

Before you make your NFL Week 1 Picks and NFL Week 2 Predictions, get the best football betting odds at and receive a 10% Deposit Bonus.