NFL Predictions: San Francisco 49ers vs. Arizona Cardinals Free NFL Picks: Arizona Cardinals quarterback Kurt Warner comes into this NFL Predictions Week 1 game winner in 9 of his 10 starts against NFC West Divisional rivals, San Francisco 49ers. According to NFL Predictions experts and Free NFL Picks specialists at SBGglobal.com, you can make it ten of eleven as the Arizona Cardinals [-6] are listed as the sports betting odds favorites to defeat the San Francisco 49ers [+6] when they step into University of Phoenix Stadium at 4:15 PM ET (1:15 PM PT) this afternoon.
The last time these NFC West foes faced each other dates back to last season’s Week 10. With a division title in 
their sights, the Cardinals, behind Warner’s 328-yard, 3-touchdown game and an exciting goal-line stand defeated the Niners 29-24. With the victory, Arizona inched closer to Frisco’s 19-16 lead in the overall head-to-head series. However, the Cards have dominated their most recent meetings by winning 6 of their past 8 encounters. The OVER/UNDER for this, NFL Predictions: San Francisco 49ers vs. Arizona Cardinals Free NFL Picks game has been calculated and set at a total of 46 points.
For the defending NFC champion Cardinals, there were some major changes made to last year’s coaching staff this offseason. None were more prominent than the firing of defensive coordinator Clancy Pendergast. After enjoying one of their most productive offensive seasons in recent years, Arizona was forced to go out and replace offensive coordinator Todd Haley, who departed to Kansas City. As a result, the Cardinals offense wasn’t the same during the preseason, as they failed to win a single game, finishing 0-4.
On a lighter note, if you will, should wide receiver Larry Fitzgerald be concerned about the “Madden Curse ”? On Thursday’s season opener, the world saw yet another NFL player fall victim to this urban myth. Steelers’ Pro Bowl safety, Troy Polamalu suffered a medical collateral ligament sprain going after a fumble caused by a blocked field goal attempt in Pittsburgh’s 13-10 overtime victory over Tennessee.
Fitzgerald, who’s on the cover of “Madden 10” with Polamalu, is coming off one of (if not) the greatest postseason performances by a wideout. In 4 playoff games, the University of Pittsburgh product registered 30 catches for 546 yards and 7 spectacular touchdowns.
For the Niners, starting quarterback, Shaun Hill will certainly be under a lot of pressure to produce if he wants to hold on to the top-spot in Frisco’s depth chart. In his first full season as head coach, Mike Singletary will be tested from Week 1 against the defending conference champs.
“I know we have a tremendous opportunity coming up this Sunday in playing the defending champions of the NFC. I’m very excited about the opportunity that we have,” Singletary wrote in his September 11 Notebook. “We’ve been preparing for this since March 16th, and we’re just continuing each day to strive to get better and compete and do the things that we need to do. Have an identity going into the season. I think we did all the things that we needed to do to prepare for the season and be ready for the first game.”
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