New England Patriots (2-1) vs. San Francisco 49ers (2-2) Betting Odds: CBSHD will broadcast this game live at 4:15 PM ET (1:15 PM PT) from Candlestick Park in San Francisco, CA. After a Bye-week, the New England Patriots look to get right back on track and avoid back-to-back regular season losses in nearly two years. In Week 3 of the NFL, the Patriots were completely humiliated by the Miami Dolphins.

The Fins went into Gillette Stadium and completed dominated New England, and handed them their first regular season loss in 21-straight games.

Odds-makers at SportsBook.com have the New England Patriots as (-3) Online NFL Week 5 Betting Odds favorites against the (+3) San Francisco 49ers at home.

The New England Patriots lost league MVP QB Tom Brady to a season-ending knee injury in the first quarter of the NFL season against Kansas City.

However, with backup QB Matt Cassel at the helm, New England won 2 straight against the Kansas City Chiefs, 17-10 and at the New York Jets, 19-10.

The Patriots have now had 2 weeks to think about their embarrassing loss to Miami. "It was one of the ugliest defeats I've ever been a part of," Patriots CB Ellis Hobbs said after the effort.

Last time the Pats were on the field, the Dolphins celebrated on their turf, and the New England fans booing their team off the field by halftime and left the game early. "The craziest thing about this loss is that not one thing beat us. ... We lost it as a team." The OVER/UNDER in this New England Patriots vs. San Francisco 49ers has been set at a combined total of 41 points.

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