Indianapolis Colts vs Jacksonville Jaguars 2010 NFL Odds, 2010 NFL Picks & 2010 NFL Predictions: Currently involved in a three-way tie atop the AFC South, the (2-1) Indianapolis Colts [-7] will look to take control of the division with a win over the struggling, sports betting odds underdog (1-2) Jacksonville Jaguars [+7]. This intradivision showdown has a scheduled opening kickoff slated for 4:05 PM ET (3:05 PM CT) and it can be seen live and in high definition on CBS Sports.
For the visiting Colts, Peyton Manning comes in looking as great as he has ever looked, as he eyes a fifth NFL 
Most Valuable Player Award. Behind Manning, the Colts will be looking for their fourth consecutive win over Jacksonville. According to Indianapolis Colts vs Jacksonville Jaguars 2010 NFL Odds, 2010 NFL Picks & 2010 NFL Predictions experts at SPORTSBOOK.com, the OVER/UNDER for this game is set at a combined total of 46 points scored.
"As odd as it seems or as hard as it is to imagine, I really do think he is getting better," Colts tight end Dallas Clark said. "It's all those little things he does, but he's really been on fire this year, just putting the ball where it's supposed to be."
The Colts defense, who’s allowing the fourth most rushing yards per game in the league will have a true test in dealing with Jacksonville Jaguards running back, Maurice Jones-Drew.
"I think the biggest stat I think most people need to worry about is how many points we allow," said Colts defensive end Dwight Freeney. "I think that's the biggest, the most important stat of them all, because that's what most matters, is who has more points at the end of the game…"
The Jags are coming off a loss to the new-look Eagles, in which Michael Vick passed for 291 yards and three touchdowns through the air. Making matters worse, is the fact that Jacksonville quarterback, David Garrard has yet to find his rhythm this season. Garrard recorded the third lowest QB-rating of his career going 13 for 30 for
"I just think collectively we all have got to play better," Garrard said. "I've got to make sure that I get the ball out faster so I don't put pressure on my offensive line. I've got to get it out faster to the right guys and allow them to make plays and to be explosive. We've got to throw the ball downfield at times, too. We just have to get back to doing what we do and I've got to get back to doing what I do."
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