New England Patriots vs San Francisco 49ers NFL Football Predictions: The Patriots are (2-1) coming off one of their worst losses in years losing at home to Miami 38-13.  The loss ended the Patriots'  NFL mark of 21 straight regular-season wins that began after a 21-0 loss to the Dolphins on Dec. 10, 2006.  The crowd booed once more when the teams went off the field at halftime, this time directing its feelings at a team that went on to lose for the first time in 16 home games.  The sports odds posted by the oddsmakers at HeroesCasino.com currently list New England Patriots -3 favorites to San Francisco 49ers heading into this matchup.

You cannot look at how the Dolphins game as a way to determine the outcome in this game.

There are some teams that have other teams numbers.  Look at the Chiefs against the Broncos.  It is going to be interesting how Mike Martz makes his game plans against that potent Patriots defense.  The Patriots have an aging, but a hell of a defense.  It is going to be difficult to contain Richard Seymour at the line.  Expect the Patriots to keep the pressure on O’Sullivan all day long, which should result in Frank Gore receiving a heavy workload. 

"It's brutal, man, brutal," Patriots defensive end Ty Warren said.  "We have to go out and regroup," Cassel said. "It is a learning situation for me playing from behind."

The 49ers (2-2) loss last week on the road to red hot New Orleans, 31-17.  QB J.T. O'Sullivan was 18/36, 257 yards, 1 TD and 2 INT's.  San Francisco's shaky run defense had trouble stopping McAllister's power running.  Having been sacked 13 times through the Niners' first three games, O'Sullivan was brought down six more times.  The big question in my mind is which JTO will show up? The one who threw for 300+ yards and had a near perfect passer rating or the one who committed 6 turnovers in two games. The online sports betting odds at HeroesCasino.com has the OVER/UNDER in this New England Patriots vs San Francisco 49ers game is set at 41 points.

NFL Football Predictions: Cassel doesn't seem to be able to do anything with the offense, I think San Fran needs to put good pressure on him, I mean really come at him.  They have a good enough secondary that they can leave their corners one on one against an inexperienced QB.   RB Gore will be a huge offensive weapon for the Niners and the Pats' rush defense has been known to shut down big-time backs, especially after a bye week and having to listen to big Bill tell them how much they sucked against the Dolphins.  The Patriots have had two weeks to stew over an embarrassing loss that snapped a 21 game regular season win streak.

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