Indianapolis Colts vs. Tennessee Titans NFL Predictions Week 5: As Pro Bowl quarterback Peyton Manning (97/137, 1336 yards, 9 TDs, 3 INTs) and the sports betting odds favorite (4-0) Indianapolis Colts [-3½] are off to a perfect start, the (0-4) Tennessee Titans [+3½] have come out of the gates in the worse way possible. Tonight, on Sunday Night Football, the unbeaten Colts have a date with the winless Titans at LP Field beginning at 8:20 PM ET (5:10 PM PT) on NBC Sports.
In their last meeting on the NFL Predictions Week 17 of last season, the Colts blanked out the Titans, 23-0. 
Overall, Indy holds a 16-13 series edge that includes the playoffs, despite the fact that Tennessee has won 3 of their last 5 encounters. By the way, the OVER/UNDER for this, Indianapolis Colts vs Tennessee Titans NFL Predictions Week 5 game has been set at a combined total of 44½ points scored.
For the visiting Colts, Manning has been absolutely phenomenal in the early going, setting a franchise record with four consecutive 300-yard games and is currently the league leader in quarterback rating (114.5). But Indy’s offense isn’t the only thing firing on all cylinders.
The Colts defense comes into this NFL Predictions Week 5 tied for fourth in NFL scoring defense and sacks, as Dwight Freeney and Robert Mathis have set the tone, each dumping the opposing quarterback 5 times each. Over the last 2 games, the Colts D-Line limited Seattle and Arizona to a combined 73 rushing yards. "What makes it fun is success," Freeney said. "That's what's going on right now around here. You build off that momentum and everything snowballs."
Meanwhile for the Titans, their 10-0 start last season now seems like light-years away. Tennessee has already lost more games coming into the NFL Predictions Week 5 than it did all of last season: 13-3 regular season record. Jeff Fisher and his bunch are off to their worse start since the 2006 season, when they began 0-5. "They'll find a way out of this, and that's all we can do," Fisher said. "I know I've said this before, but you come back and you work and you try to find a way to win the next game and keep your focus on improving."
As far as changing quarterbacks is concerned, Fisher is sticking with his vet, who’s currently the NFL’s 28th-rated passer. Vince Young is ready to go, and one has to think that another poor start from Collins would likely give the former Texas Longhorn a shot. Even though Collins already has as many interceptions in four weeks (6) as he did all of last season (7), coach Fisher stated that, "Kerry's not the problem".
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