NFL Predictions Week 10 – Giants vs 49ers Odds: The banged up Giants are in San Francisco today to face the NFC West leading 49ers at Candlestick Park. This afternoon's high profile NFC skirmish is scheduled to get underway at 4:15m ET on FOX. The hosting Niners have been installed as a =3.5 against the spread favorite by NFL odds makers while the game total has been set at 42.5 points. Stay in the NFL Predictions loop and get the latest Giants vs 49ers Odds before making your pick on today's game.
The Giants just cannot seem to stay 
healthy as they are, at least in terms of injury, the most snake bit team in the league. New York's physical ailments have greatly affected both sides of the ball and they will again today.
As of right now, wide receivers Hakeem Nicks and Mario Manningham are listed as questionable as is center David Baas. Running back Ahmad Bradshaw can only wish his status were so positive as he is out for a second straight week with a broken foot.
But if there's any team that knows how to play through injury, it is these Giants. New York has been weathering this storm since the season kicked off, yet it has still compiled an impressive 6-2 record while going 3-1 away from home.
The Giants mental and physical toughness will be tested in a big way today, though, with the surprising 49ers looking to protect their home turf against potential playoff competition.
The 7-1 Niners ride a six game win streak into today's contest and they are 3-1 on the season at Candlestick Park. Only the Cowboys were able to handle what San Francisco had to offer and they needed overtime to slip past Jim Harbaugh's tough-as-nails squad.
At some point, though, someone is going to end the Niners win streak. San Francisco, while good, does not look like a great team just yet. The team's occasional offensive shortcomings will leave it exposed at some point and that may come today against a Giants team that clearly knows how to win in the most difficult of circumstances.
NFL Predictions Betting Trend: The Giants are 8-2 straight up and against the spread in their last 10 games as a road dog with a spread between 0 and 3.5 points.
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NFL Predictions Week 10 – Giants vs 49ers Odds: Provided by JustBet.cx
New York Giants +3.5 (-110), Over 42.5 (-110)
San Francisco 49ers -3.5 (-110), Under 42.5 (-110)
