NFL Picks: New England Patriots vs. Indianapolis Colts NFL Betting Odds Week 10: It has been called the “rivalry of the decade” and this NFL Betting Odds Week 10, the eyes of the NFL Picks world will be on this incredible, AFC championship-caliber matchup. Just a few years ago, the (6-2) New England Patriots [+2½] had a perfect 16-0 regular season, before losing to the Giants in the Super Bowl. This NFL Picks season, the sports betting odds favorite (8-0) Indianapolis Colts [-2½] are making their own bid at history, but are only halfway there.
Lucas Oil Stadium will be the sight for this AFC mega-showdown between divisional leaders on NBC’s Sunday 
Night Football. According to NFL Picks and NFL Betting Odds Week 10 specialists at SBGglobal.com, the OVER/UNDER for this New England Patriots vs. Indianapolis Colts game has been set at a combined total of 48 points scored.
For the visiting Patriots, 2007 NFL MVP Tom Brady and Bill Belichick would like nothing more than to put an end to any hopes 2008 league MVP Peyton Manning and the Colts may have of a perfect season. "It will be a little different looking across the sideline not seeing Tony (Dungy)," Patriots coach Bill Belichick said. "(But they're) 8-0, leading the league in defense in points allowed.
“They're a team offensively that can pretty much do whatever they want to do or need to do. I don't think they are limited in any way. They never have been and they certainly don't look like it now."
For the Colts, their success has continued despite Dungy retiring and leaving first-year coach Jim Caldwell in charge. As they’ve shown through out the years, not even injury to key players can stop this Colts machine, which is playing at its highest level at the moment. Speaking of high level of play, how about that boy named Peyton?!
"He's just the ultimate quarterback," Pats cornerback Leigh Bodden said of Manning. "There's a route and a run to beat every coverage or defensive front. So he looks at it, he surveys it and he checks out of whatever play he's in to go to a better play and he has a lot of weapons and he can put the ball on the money in tight coverage."
But just as the Pats are full of compliments for the opposing QB, the Colts feel the same way about a man already considered a living legend. "They've been on a roll lately, just watching them on Sunday games," Indy’s (CB) Jerraud Powers said of the Patriots. "Tom looked like he was back to his old self. They look like they're clicking on all cylinders. I'm pretty sure this will be a fun one."
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