Virginia vs Clemson College Football Odds Picks: The Clemson Tigers will be trying to pick up a win on Saturday when they battle the Virginia Cavaliers at Memorial Stadium and in doing so would win the ACC Atlantic Division and the ACC title game.  Death Valley is an intimidating place and with Heisman Candidate C. J Spiller all over the field Virginia is in for a long day. The Tigers (7-3, 5-2) lost three of its first five games by a total of 10 points, falling by three at Georgia Tech and four at home to TCU - both teams now ranked in the top 10.  My College Football Odds Picks have Clemson winning big and covering the spread at home so give the points to win. The College Football Picks Odds makers at Sportsbook.com have the Clemson Tigers -21 point favorites against the Virginia Cavaliers.

Virginia gave up a fourth-quarter touchdown to get beaten 14-10 by Boston College at Scott Stadium in Week 11. Boston College covered as a 4.5-point road favorite while the final score played UNDER the 44-point total. Virginia is 4-1 ATS in its last 5 games on the road and the total has gone UNDER in 4 of Virginia's last 5 games. The College Football Picks Odds experts at sportsbook.com have the Clemson Tigers vs. Virginia Cavaliers Total set at 45 points.

C.J. Spiller became the first player in Clemson history to record a touchdown passing, rushing and receiving in the same game, leading the way as the Tigers beat North Carolina State 43-23 in Week 11. The Tigers covered the 8-point spread, while the final score played OVER the day's posted total of 55.5.

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