Jacksonville Jaguars vs San Francisco 49ers NFL Week 12 Picks: The Jacksonville Jaguars have won three in a row and the San Francisco 49ers have won one of their last five and on Sunday at 4:05 PM ET they meet at Candlestick Park. David Garrard quarterbacked just three game-winning drives in his first 58 career starts and now has had two in a row which has the Jaguars back in the playoff race tied for the wild card spot.  The 49ers are not in such a good spot, after a strong start the 49ers are 2 games back of the Wildcard race with a handful of teams in front of them.  My NFL Week 12 Picks have the Jags winning on the road so take the points to win. The NFL Week 12 Picks experts at online sportsbook Bodog.com have the San Francisco 49ers -3.5 point favorites against the Jacksonville Jaguars.

Jacksonville came back and defeated Buffalo 18-15 as an 8.5-point favorite in Week 11. The combined score fell UNDER the posted over/under total (41). David Garrard threw for 215 yards with a touchdown and an interception for the Jaguars and Maurice Jones-Drew ran for 66 yards and a touchdown on 25 carries.  "It's just something that continues to give this team, this offense, confidence," Garrard said. "You're not going to get it every time, but when you do, you've got to relish it, learn from it and understand what it's like to be in that moment." The NFL Week 12 Picks experts at Bodog.com have the 49ers vs. Jaguars Total set at 41.5 points.

The 49ers upset Green Bay 30-24 as a 6-point underdog in Week 11. The combined score went OVER the posted over/under total (42). Alex Smith passed for 227 yards with three touchdowns and an interception for San Francisco, while Vernon Davis had six receptions for 106 yards and a TD.

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