NFL Picks: Indianapolis Colts vs. Houston Texans NFL Odds Week 12: Reliant Stadium in Space City will be the sight for this very entertaining AFC South divisional showdown between the perfect, (10-0) Indianapolis Colts [-3½] visiting the explosive, sports betting odds underdog (5-5) Houston Texans [+3½]. This NFL Picks game’s opening kickoff will be put in play at around 1:05 PM ET and you can catch all the hard-hitting action live on CBS Sports.

According to NFL Odds makers at Bodog.com, the OVER/UNDER for this Indianapolis Colts vs. Houston Texans Week 12 showdown has been calculated and set at a combined total of 47½ points scored.

The Colts enter this NFL Odds Week 12 having reached double-digits in wins and have yet to lose a game this season. Nevertheless, Indy has been anything but perfect over the last three weeks, escaping in each of those games by a field goal or less.

“We certainly feel we've developed a pretty solid mental toughness," first-year coach Jim Caldwell said. "Hopefully, it's going to serve us down the road and make us continue to get better. Hopefully we can benefit from it."

But with a comfortable 3-game lead in the AFC standings, Peyton Manning is looking to inch closer to clinching a playoff spot and then start working on securing the best record in the conference. In fact, with a Jacksonville loss and a win against the Texans, this can be accomplished this wee, as the Colts would easily clinch the division.

Going into this NFL Odds Week 12, Indianapolis has now won 19 consecutive games, second largest in NFL history behind the Patriots 21-game stretch from 2006-2008.

For the Texans, their playoff hopes are sinking fast. After entering their NFL Odds Week nine matchup with Indy riding a 3-game win streak, Houston has gone on to lose consecutive, 3-point contests. Last week, Kris Brown missed a potential game-tying 49-yard field goal attempt, as the Texans fell to Tennessee on Monday Night.

"We know what kind of capabilities we have, and this is a very young, good football team," linebacker Brian Cushing stated this week. "It's just been so disappointing with the way we've lost games, but it happens. We are not going to sulk."

If these guys want to have any chance at finally playing past January 3rd, they need to put something together fast, starting today. "We just need to win," said receiver Andre Johnson. "That's all that matters. If we win the rest of our games, we get in. If we don't we will be packing our bags at the end of the season again. I don't really think about (playoffs), we just have to win."

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