NFL Picks: Jacksonville Jaguars vs. San Francisco 49ers NFL Odds Week 12: Still hanging around in the playoff race, the often-overlooked (6-4) Jacksonville Jaguars [+3] travel to old Candlestick Park on the East Bay to take on the sports betting odds favorite (4-6) San Francisco 49ers [-3] this NFL Odds Week 12.
This inter-conference game is scheduled to kickoff right around 4:10 PM ET (1:10 PM PT) and it can be seen on CBS Sports. According to NFL Picks specialists and NFL Odds makers at SBGglobal.com, the OVER/UNDER set 
forth for this Jacksonville Jaguars vs. San Francisco 49ers Week 12 showdown has been set at a combined total of 41½ points scored.
The Jags enter this week sitting in second place in the AFC South, thanks to an impressive 3-game win streak. Despite being four games back of the undefeated Colts, Jacksonville has won 5 of its 7 divisional games and is now just one game behind Denver for the final AFC playoff spot.
"We're not content, we're not comfortable," Jaguars wide out, Mike Sims-Walker said. "We know we still have a lot of work to put in and a lot of work to do to reach the playoffs. We've got to keep fighting. We're not letting up at all."
For the Niners, their blistering 3-1 start now seems like a distant memory, as they’ve lost four of their last five games. Nevertheless, Frisco head coach Mike Singletary has yet to given up on his team’s hopes to make a late playoff run.
"At the very start of the season, our goal was to win enough games to go to the playoffs. That is still our goal. That will not change," said Singletary. "We're a team, in my mind, good enough to do that. We're running out of games, and we're running out of time."
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