The Jacksonville Jaguars can take a huge step toward securing the AFC South title this weekend when they take on the Colts in Indianapolis. Sunday's battle between the two division rivals is scheduled to get underway at 1:00pm ET at Lucas Oil Stadium. NFL Week 15 Predictions have the Colts listed as a -4.5 against the spread home favorite and the game total set at 48.5.
At 8-5, the Jaguars own a one game lead 
over the Colts coming into this weekend's game, and with a win, they will almost certainly wrap up the division. Jacksonville has played nearly flawless football over the last six games, going 5-1 in that span, with its only loss coming to the Giants in New York.
The Jaguars added another feather in their cap this past Sunday with a come from behind 38-31 victory over the Raiders at EverBank Field. Jacksonville trailed 17-7 at halftime, but rallied for four second half touchdowns to maintain their lead over Indy. David Garrard threw three touchdown passes in the win while Maurice Jones-Drew, who scored the game winning touchdown on a 30 yard scamper, tallied 101 yards on 23 carries.
The Jaguars, thanks to a five carry, 105 yard performance from backup running back Rashad Jennings, rushed for 234 yards in dispatching Oakland.
Indianapolis ended a rare three game skid and brought its record to 7-6 last Thursday night with a 30-28 win at Tennessee. Peyton Manning, who had tossed 11 interceptions in the Colts losing streak, bounced back from one of the roughest stretches of his career with his second best performance of the season.
Manning completed 25-of-35 passes for 319 yards and two touchdowns (118.6 passer rating) in leading the Colts to 21 first downs and 399 total yards. Wide receivers Reggie Wayne and Pierre Garcon combined for 10 catches, 199 yards, and two scores in the win.
Indianapolis has won seven of its last nine home games against the Jaguars, but the majority of those victories did not come easily. Jacksonville's last two losses at Indy have been by a combined five points, and it has covered the spread in five of its last six meetings with the Colts in Indianapolis.
NFL Week 15 Predictions Betting Trend: The Jaguars are 5-0-1 against the spread in their last six games at Indianapolis.
NFL Week 15 Predictions Jacksonville Jaguars vs Indianapolis Colts Odds:
Jacksonville Jaguars +4.5 (-110), Over 48.5 (-110)
Indianapolis Colts -4.5 (-110), Under 48.5 (-110)
