NFL Picks San Francisco 49ers (5-9) vs. St Louis Rams (2-12): Edward Jones Dome will be the sight for this old NFC West showdown between the San Francisco 49ers and the St. Louis Rams. All the action in this one kicks off at 1:05 PM ET (10:05 AM PT) and it can be seen live on your regional FOX and/or Direct TV’s NFL Sunday Ticket.
With a combined 21 losses, neither the 49ers nor the Rams have any playoff aspirations, as they’ll be playing for pride, and NFC West bragging rights. 
Odds-makers at SBGglobal.com are quick with the best Sports Odds for this NFC West NFL Picks match up between the betting favorites San Francisco 49ers [-5] taking on the hosting underdogs, St. Louis Rams [+5] .
Both clubs will not only be playing for themselves, but more so, each will be making a case for their respective interim coaches returning next season. The Niners’ Mike Singletary is looking to win for the 3rd time in four games. Meanwhile, the Rams and Jim Haslett are trying to avoid losing 9 straight games for the first time in 17 years. AT SBGglobal.com, 42 points have set as the OVER/UNDER for this, NFL Picks: San Francisco vs. St. Louis Rams game.
The last time these two NFC West rivals met dates back to Week 11, when San Francisco’s QB Shaun Hill threw for 213 yards and 2 TDs to lead the Niners over the Rams, 35-16. Presently, Frisco has won 2 of the past 3 matchups, but the Rams hold a 60-55-2 overall series lead.
